AM-4030 is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-((E)-3-hydroxyprop-1-enyl) group. This adds a \"southern\" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-4030 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a double bond with defined stereochemistry. This gives AM-4030 a greater degree of selectivity, so while it is still a potent agonist at both CB1 and CB2, it is reasonably selective for CB1, with a Ki of 0.7nM at CB1 and 8.6nM at CB2, a selectivity of around 12x. Resolution of the enantiomers of AM-4030 yields an even more potent compound, although with less selectivity, with the (−) enantiomer AM-4030a having a Ki of 0.6nM at CB1 and 1.1nM at CB2.
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{"type":"standard","title":"Clover Lea","displaytitle":"Clover Lea","namespace":{"id":0,"text":""},"wikibase_item":"Q14712190","titles":{"canonical":"Clover_Lea","normalized":"Clover Lea","display":"Clover Lea"},"pageid":39991000,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/7/73/Clover_Lea_gate_and_wing_walls.jpg/330px-Clover_Lea_gate_and_wing_walls.jpg","width":320,"height":213},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/7/73/Clover_Lea_gate_and_wing_walls.jpg","width":6016,"height":4000},"lang":"en","dir":"ltr","revision":"1271228262","tid":"5091d13e-d935-11ef-b990-dc7666155299","timestamp":"2025-01-23T02:54:08Z","description":"Historic house in Virginia, United States","description_source":"local","coordinates":{"lat":37.64333333,"lon":-77.18527778},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Clover_Lea","revisions":"https://en.wikipedia.org/wiki/Clover_Lea?action=history","edit":"https://en.wikipedia.org/wiki/Clover_Lea?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Clover_Lea"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Clover_Lea","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Clover_Lea","edit":"https://en.m.wikipedia.org/wiki/Clover_Lea?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Clover_Lea"}},"extract":"Clover Lea is a historic home located near Mechanicsville, Hanover County, Virginia. It was built in 1845–1846, and is a two-story, three-bay, side-hall-plan brick dwelling in the Greek Revival style. The house features a two-story, Tuscan order-inspired portico which consists of six massive square wooden columns supported by brick piers. Also on the property is a contributing small carriage barn.","extract_html":"
Clover Lea is a historic home located near Mechanicsville, Hanover County, Virginia. It was built in 1845–1846, and is a two-story, three-bay, side-hall-plan brick dwelling in the Greek Revival style. The house features a two-story, Tuscan order-inspired portico which consists of six massive square wooden columns supported by brick piers. Also on the property is a contributing small carriage barn.
"}